Summary:
- What It Does: Injectable polynucleotides help improve overall skin quality and support skin rejuvenation, suited for thin, weakened or post-acne skin.
- Downtime: REJURAN® downtime is mild. Patients may experience slight swelling or small bumps, which usually subside within 24-48 hours.
- Protocol: 3–4 sessions, spaced 3–4 weeks apart. Results typically last 9 to 12 months with maintenance.
- How Long REJURAN® lasts: Typically lasts 9 to 12 months with maintenance.
- How It Compares: While lasers and microneedling rely on controlled micro-trauma to trigger a healing response, Rejuran provides biological 3D scafold that actively restore and strengthen the skin's foundation.
- Cost: $300–800 per session in Singapore.
- Who Should Avoid: Pregnancy, breastfeeding, autoimmune conditions, or clotting disorders. However, these are not absolute contraindications and suitability is assessed by a doctor based on risks and benefits.
Curious about what is REJURAN®? This guide explains REJURAN® polynucleotide treatment in clear, practical terms. You will learn how it supports skin repair from within, what downtime realistically looks like, how long results usually last, and how this injectable compares with lasers or microneedling for skin rejuvenation and acne scar refinement.
How REJURAN® Repairs Skin from the Inside Out
REJURAN® improves the skin by repairing it from within. Instead of targeting surface lines, it focuses on strengthening the skin barrier itself. Rather than mechanically filling lines or ablating tissue, this approach supports cellular repair processes associated with skin regeneration, strengthening the skin matrix over time.
Why DOT™-Polynucleotides (DOT™ -PN) Outperform Over-the-Counter PDRN
You may have seen PDRN in calming serums or masks. These products help soothe the skin but work on the surface.
Polynucleotides (PN) are the active ingredient in REJURAN® injectables. PN molecules are longer and larger than DNA fragments derived from wild salmon. Studies have shown that DOT™ -PN has the highest nucleotide similarity ratio to humans, which contributes to improved biocompatibility and a lower likelihood of immune-related responses.
This allows PN injections to stimulate the skin’s natural reparative capabilities and processes linked to collagen renewal, offering longer-lasting improvements compared with over-the-counter PDRN products.
REJURAN® Downtime: What to Expect After Each Session
REJURAN® promotes skin repair while keeping downtime short, so results show with little disruption.
Typical Recovery Timeline
The milestones below show the usual pace of healing
- After the Treatment: Micro-papules, light warmth and redness.
- Day 1–2: Bumps begin to flatten or fade; mild puffiness and a pink tone may linger. Many feel comfortable returning to work with breathable make-up.
- Day 3:Papules are largely gone. Skin can feel slightly tight as dermal repair pathways activate.
- Day 4–7: Surface recovery completes. Subtle improvements in glow and hydration become noticeable.
Normal Signs vs Warning Signs During the Healing Process
Check the table to see which healing signs are normal and when to call your doctor.
| Normal Healing Signs | Warning Signs | |
|---|---|---|
|
Bumps |
Small bumps that flatten within 24–72 hours.
|
Hard lumps that persist beyond 14 days or feel increasingly painful.
|
|
Skin Colour
|
Mild pinkness or redness that fades within 2 days; minor bruising.
|
Pale/white patches or a net-like, purple pattern (mottling).
|
|
Discomfort Level
|
Mild tenderness when the face moves.
|
Throbbing, or escalating pain that doesn’t improve with time. |
|
Surface
|
Tiny, dry pin-prick scabs that fall off naturally.
|
Presence of pus, yellow discharge, or clusters of blisters/sores.
|
Your REJURAN® After-Care Checklist
Simple habits during the first week help the treatment settle and support steady collagen build-up.
Skincare, Sunblock and Lifestyle Do’s & Don’ts
Recommended practices for the first 7 days after REJURAN® treatment:
- Cleanse twice daily with a pH-balanced, fragrance-free wash for 3 days.
- Apply REJURAN® Turnover Ampoule and REJURAN® Moisturiser in the morning and night.
- Use a REJURAN® sunscreen or REJURAN® UV protection cream every morning, including indoors. Top up when necessary.
After completing the full treatment course, results tend to last because REJURAN® enhances skin quality rather than providing a quick surface fix.
Activities and skincare to avoid during the same period:
- Facial scrub, peel, or mechanical or chemical exfoliants for 7 days
- Retinoids, hydroxy acids or vitamin C
- Saunas, steam rooms or high-intensity exercise for 48 hours.
Treatment Duration & Clinic Schedules
Sessions are spaced to give the skin time to repair and strengthen the skin barrier gradually for more consistent results.
How Many Sessions Singapore Doctors Recommend
Doctors recommend an initial course of 3–4 sessions. While some improvements, such as smoother texture and a healthy glow, may be noticeable after a single session, repeated treatments help deliver more consistent results. Over a series of sessions, skin quality is gradually enhanced, including improved elasticity, refined pore appearance, and stronger overall skin health. Maintenance treatments are usually recommended every 6–9 months.
Initial sessions are spaced 1 month apart. This interval matches the skin’s natural turnover cycle of about 28 days. Each treatment builds on the last, allowing polynucleotides to create a favourable physiological condition that stimulates the skin’s natural reparative and restorative capabilities, improving elasticity by restoring the biological condition of the dermis and epidermis.
How Long Does REJURAN® Last Before You Need a Top-Up?
After the initial course, results last because REJURAN® encourages the skin to produce new collagen rather than creating a temporary surface effect.
- Duration: Firmer, more supple skin typically lasts for approximately 9 to 12 months.
- Maintenance: 1 booster every 9 to 12 months helps maintain results.
Unsure which skincare pairs well with REJURAN® injections?
With the wrong match, you risk irritation or wasted products. Browse our range of products — cleansers, moisturisers and SPF for a gentle post-treatment routine.
Is REJURAN® the Right Choice for You?
REJURAN® suits those who want to strengthen thin skin, soften fine lines, or refine acne scars without laser heat. REJURAN® is safe for all ethnicities and skin shades, providing a versatile option that complements most non-energy-based procedures. If gradual improvements in tone, hydration, and dermal quality appeal to you, this polynucleotide treatment may be a good fit.
Who Should Avoid REJURAN® Injections
REJURAN® is generally well tolerated; however, certain individuals may require extra caution or alternative treatment options. As clinical data in these areas is limited, consultation with a qualified medical professional is recommended before proceeding.
- Pregnancy or breastfeeding
- Active skin infections
- Severe allergies or a history of anaphylaxis
- Autoimmune diseases such as lupus or rheumatoid arthritis
- Blood-clotting disorders or the use of anticoagulant or immunosuppressant drugs
- Pronounced tendency to form keloids or hypertrophic scars.
REJURAN®, Laser or Microneedling—Which Fits Your Goals?
All 3 treatments stimulate collagen, yet each differs in downtime, pigment safety and the type of concerns it tackles best.
| REJURAN® (PN) | Fractional CO2 Laser | RF Microneedling | |
|---|---|---|---|
|
Primary Goal
|
Cellular Repair & Health
|
Surface Resurfacing
|
Deep Tissue Remodelling
|
|
Downtime
|
2–3 days (small bumps)
|
5–7 days (redness/peeling)
|
2–3 days (pinkness)
|
|
Pain Level
|
Low to Moderate
|
Moderate to High
|
Moderate |
Downtime, Pigment Risk and Efficacy
High-intensity lasers can be effective but carry a higher risk of post-inflammatory hyperpigmentation, especially in darker skin tones.
REJURAN® is preferred for sensitive or pigment-prone skin because it does not use heat. Compared with thermal laser devices, it typically carries a lower risk of pigment disturbance. Lasers offer faster surface smoothing, while REJURAN® delivers gradual improvement by strengthening the skin from within.
How Efficient Is REJURAN® for Acne Scars and Fine Lines?
Clinical research points to steady results after a few sessions.
- Collagen & Texture: Increased fibroblast activity and improvements in dermal quality following PN exposure, supporting improvements in skin texture and dermal density.
- Fine Lines & Wrinkles: A 2024 systematic review covering 9 studies found that polynucleotide led to significant drops in wrinkle scores and measurable boosts in skin elasticity.
- Atrophic Acne Scars: PN injections reduced scar depth and improved dermal texture after a short course of treatments.
Cost of REJURAN® in Singapore
The cost of REJURAN® in Singapore generally ranges from $300–800 per session. Prices can vary based on the clinic, the REJURAN® selected, the treatment area and the doctor’s level of experience.
Need More Details on REJURAN®? Let Our Team at DermaRev Guide You
Curious to learn how REJURAN® could fit your skin goals? Contact DermaRev at enquiry@dermarev.com.sg for personalised advice today!
